P-475 Effect of transdermal estradiol on endometrial preparation in frozen-thawed embryo transfer: A randomized control study.

Abstract Study question Is patient usage of transdermal estradiol more effective than oral on endometrial preparation in frozen-thawed embryo transfer cycles? Summary answer This study showed no significant differences clinical pregnancy rates between the 2 groups. Transdermal gel have advantage better comfort, lesser side effects. What is known already Estrogen and progesterone are crucial factors for frozen (FET) cycles. Studies assessing different forms FET been published. However, literature studies Vietnam still limited to evaluating, research evaluating estrogen ART. aimed evaluate use compare it with endometrium design, size, duration randomized trial (RCT) included 380 cycles from February 2020 August 2021 at IVF Department, Hung Vuong Hospital. Participants/materials, setting, methods They were into one two Group A (n = 190) received group B gel. In both groups, medication was started day menstrual, thickness monitored by ultrasound. Main outcomes following: serum level , thickness,.... Secondary CPR, MR, effects Statistical testing performed Stata 14. results role chance There a difference administration groups (270.5 pg/ml versus 186.5 pg/ml, p, p. <0.001). According comparison, not significantly (p 0.85). as data suggest, total dose used number days dosing similar The biochemical did differ (56.2% vs. 52.2%, p 0.474). rate miscarriage higher group, but statistically significant. Almost 20.3% patients 37) had mild adverse when compared only 10.1% 18) B, this clinically (P 0.007). Limitations, reasons caution limitation our asses ongoing live-birth rate. Wider implications findings Patients who valerate contraindicated such as, high risk deep vein thrombosis, hyperlipidemia, clotting disturbance we can oestrogel be safe. It suggested that patches instead Trial registration ISRCTN15301227